Lumify increases short-term tear breakup time in patients with, without dry eye
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NASHVILLE, Tenn. — Short-term noninvasive tear breakup time increased with use of Lumify eye drops in cohort of patients with and without dry eye disease, according to a poster presented at Optometry’s Meeting.
“Ocular redness is a very common patient complaint and when it is associated with nonsignificant pathology in our offices, we may want to recommend an over-the-counter vasoconstrictor,” Melissa Toyos, MD, partner and research director at Toyos Clinic in Nashville and New York City, said in an online presentation.
Bausch + Lomb’s Lumify (brimonidine tartrate ophthalmic solution 0.025%) is a selective alpha-2 adrenergic receptor agonist with a relative binding affinity of about 1,000:1 — significantly different than OTC vasoconstrictors currently on the market, which have ratios of 2:1 or 5:1, Toyos said. The vehicle of brimonidine tartrate is glycerin and it also contains benzalkonium chloride and boric acid.
In a prospective, nonrandomized, non-masked study of 26 participants with and without dry eye, researchers used the Oculus Keratograph 5M to evaluate changes in noninvasive TBUT 15 minutes after instillation of a single drop of brimonidine tartrate.
Prior to instillation, the average TBUT was 6.25 seconds, which rose to an average of 9.11 seconds after 15 minutes. The minimum TBUT before and after instillation was 1.72 seconds and 2.68 seconds, respectively, while the maximum was 17.59 seconds and 21.41 seconds.
“Dry eyes, especially, are sensitive eyes and eyes that are experiencing redness are often dry,” Toyos said. “When we instill something to reduce the redness that can be associated with pathologies like dry eye or ocular allergy, we want to be sure that patients aren’t suffering with their ocular surface.”
She added, “What we showed here was that brimonidine tartrate — and especially with the moisturizers included in the formulation — seemed to be very helpful in increasing the tear breakup time at least immediately post-instillation.”
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Moore A, et al. Improvement in noninvasive tear break-up time after instillation of one drop of brimonidine tartrate 0.025%. Presented at: Optometry’s Meeting; June 19-22, 2024; Nashville, Tennessee.
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