High-resolution aberrometer prototype shows keratoconus-specific micro alterations
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Key takeaways:
- A high-resolution aberrometer prototype showed the ability to precisely measure aberrations in keratoconus vs. healthy eyes.
- Micro alterations were visible in the wavefront phase of keratoconus eyes.
VILAMOURA, Portugal — A high-resolution aberrometer prototype using astrophysics technology revealed unprecedented micro alterations in the wavefront phase of keratoconus eyes, which are dependent on the disease stage.
At the European Society of Cataract and Refractive Surgeons winter meeting, Gonzalo Velarde-Rodriguez, MD, presented the results of a study in which this high-resolution (8.6 µm) prototype aberrometer, called T-eyede (Wooptix), was used in 43 healthy eyes and 43 eyes with keratoconus at various stages. Corneal aberration values were provided by Pentacam tomography (Oculus), and ocular aberrations were obtained from intensity images captured by T-eyede. In addition, image processing analysis of the wavefront was performed, creating a high-pass filter map.
“As expected, a higher amount of aberrations was seen in the keratoconic eyes, not only coma but also astigmatism and [higher-order aberrations], and the difference was statistically significant,” Velarde-Rodriguez said. “In addition, we noticed two different representation patterns in the wavefront phase, a smooth pattern that was present in 95% of the healthy eyes, and what we called a rough pattern, exhibited by 77% of the keratoconic eyes.”
The stage of keratoconus had an important role in showing this rough, uneven filtered map.
“We found it in 75% of stage I, 90% of stage II and 100% of stage III keratoconus,” Velarde-Rodriguez said.
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Velarde-Rodriguez G, et al. High-resolution wavefront analysis in keratoconus applying new astrophysics technology: A cross-sectional study. Presented at: European Society of Cataract and Refractive Surgeons winter meeting; March 10-12, 2023; Vilamoura, Portugal.
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