VIDEO: Unmet needs in CML treatment

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Understanding pharmacologic differences and response. In other words, is there a way for us to tell who will get the right amount? Who needs a lesser dose? Who needs a greater dose? We do it sort of by looking at their molecular response and trying to bump it a little or looking at side effects and trying to bring it down. It's not terribly scientific. It would be nice if we were able to do that in a more rational way. The other is mutations and understanding what to do as people develop mutations. When can we take people off? How long can we take them off? Will it decrease the mutations that can develop? And why do certain people develop the mutations and others do not?