Drinking moderate amounts of caffeine may cut risk for multiple cardiometabolic diseases
Click Here to Manage Email Alerts
Key takeaways:
- Drinking about three cups of coffee daily conferred the lowest risk for multiple cardiometabolic diseases.
- A lower risk for multiple cardiometabolic diseases was tied to 100 mg or more caffeine intake daily.
Adults who drink caffeinated beverages such as coffee or tea may have a lower risk for developing multiple cardiometabolic diseases compared with adults with low or no intake, according to study findings.
In an analysis of data from the UK Biobank published in The Journal of Clinical Endocrinology & Metabolism, researchers found drinking 100 mg caffeine or more per day lowered the risk for cardiometabolic disease including type 2 diabetes, coronary heart disease and stroke compared with drinking less than 100 mg caffeine per day. The largest risk reduction was seen among those consuming 2.6 to 3.5 drinks of coffee per day or 200 mg to 300 mg caffeine daily.
“The findings highlight that promoting moderate amounts of coffee or caffeine intake as a dietary habit to healthy people might have far-reaching benefits for the prevention of cardiometabolic multimorbidity,” Chaofu Ke, MD, PhD, associate professor in the department of epidemiology and biostatistics, School of Public Health at Suzhou Medical College of Soochow University in China, said in a press release.
Researchers obtained data from adults aged 37 to 73 years in the UK Biobank who did not have multiple cardiometabolic diseases at baseline. Cardiometabolic multimorbidity was defined as being diagnosed with at least two of the following diseases: type 2 diabetes, CHD or stroke. Coffee, tea and caffeine intake were obtained from 24-hour dietary recalls.
There were 172,315 adults included in the caffeine analysis and 188,091 participants included in the coffee and tea analysis. During a median follow-up of 11.68 years, 0.76% in the caffeine group and 0.74% in the coffee and tea group developed two or more cardiometabolic diseases. Of adults included in the caffeine analysis, 78.83% reported a daily caffeine intake of more than 100 mg.
Compared with adults who did not drink coffee, a lower risk for multiple cardiometabolic diseases was observed for participants who drank 1.5 coffee drinks or less per day (HR = 0.71; 95% CI, 0.61-0.82), those who had 1.6 to 2.5 coffee drinks per day (HR = 0.69; 95% CI, 0.58-0.83), adults who drank 2.6 to 3.5 servings of coffee per day (HR = 0.52; 95% CI, 0.42-0.65), those who had 3.6 to 4.5 coffee drinks per day (HR = 0.61; 95% CI, 0.47-0.78) and participants who drank more than 4.5 servings of coffee per day (HR = 0.66; 95% CI, 0.5-0.88).
Adults who had 1.6 to 2.5 drinks of tea (HR = 0.66; 95% CI, 0.55-0.8), 2.6 to 3.5 servings of tea (HR = 0.72; 95% CI, 0.59-0.87), 3.6 to 4.5 drinks of tea (HR = 0.62; 95% CI, 0.5-0.78) and more than 4.5 drinks of tea daily (HR = 0.6; 95% CI, 0.47-0.77) were less likely to develop multiple cardiometabolic diseases than adults who did not drink tea.
Compared with adults who drank 100 mg or less of caffeine daily, those who had caffeine intake of 101 mg to 200 mg (HR = 0.78; 95% CI, 0.67-0.9), 201 mg to 300 mg (HR = 0.59; 95% CI, 0.5-0.7), 301 mg to 400 mg (HR = 0.63; 95% CI, 0.5-0.79) and more than 400 mg (HR = 0.6; 95% CI, 0.43-0.83) were less likely to develop multiple cardiometabolic diseases.
Researchers identified 80 plasma metabolites related to moderate coffee drinking and the development of multiple cardiometabolic diseases. Of those metabolites, 37 were negatively associated with moderate coffee intake and were most frequently tied to the expression of very LDL subclasses. There were 43 metabolites positively associated with moderate coffee intake, with the most frequent associations tied to the expression of HDL subclasses.
There were 97 plasma metabolites associated with drinking five or more servings of tea per day and the development of multiple cardiometabolic disorders, of which 60 were inversely associated with tea intake. Eighty-one metabolites were associated with both the development of multiple cardiometabolic disorders and caffeine intake of 201 mg to 300 mg per day, with 42 of those metabolites inversely associated with moderate caffeine intake.
The researchers wrote that the metabolites could help with identifying potential molecular intervention targets in the future.
“Future studies are warranted to gain a more in-depth insight into the pathway from coffee, tea and caffeine intake to circulating metabolites and then to cardiometabolic multimorbidity,” the researchers wrote.
Reference:
Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds. https://www.newswise.com/articles/moderate-coffee-and-caffeine-consumption-is-associated-with-lower-risk-of-developing-multiple-cardiometabolic-diseases-new-study-finds. Published Sept. 17, 2024. Accessed Sept. 17, 2024.
Collapse
Read more about
Click Here to Manage Email Alerts