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Neuroendocrinology News

Older adults with Cushing’s disease present with fewer symptoms than younger patients
The presentation of Cushing’s disease varies by age, with older adults having fewer hallmark features of the condition and more comorbidities, according to study findings published in The Journal of Clinical Endocrinology & Metabolism.
Endocrinology Drug and Device Update
In a review of the 2024 milestones, Healio | Endocrine Today compiled a list of drugs and devices related to the field that were newly approved, cleared or had label or indication changes. Information was gathered from the FDA website and news releases. We put our best effort into making a complete list and regret any omission. Appearance of a drug or device does not constitute any endorsement by Healio | Endocrine Today, its editors, publishers or editorial board. — The Editors
Relacorilant improves cardiometabolic metrics for patients with Cushing’s syndrome

Among patients with endogenous hypercortisolism, relacorilant improved cardiometabolic parameters such as blood pressure, HbA1c and weight, according to results of a long-term extension study.
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Mifepristone reduces HbA1c in patients with hypercortisolism, type 2 diabetes

In patients with hypercortisolism and difficult-to-control type 2 diabetes, mifepristone lowered HbA1c at 24 weeks compared with placebo, researchers reported at World Congress on Insulin Resistance, Diabetes & Cardiovascular Disease.
Crinecerfont approved to treat congenital adrenal hyperplasia

Neurocrine Biosciences announced that the FDA has approved crinecerfont as an adjunct to glucocorticoid replacement to control androgens for patients with congenital adrenal hyperplasia.
AI model using voice recognition outperforms endocrinologists for diagnosing acromegaly

A machine learning model was more accurate than 12 experienced endocrinologists in identifying adults with acromegaly based on voice recordings, according to findings published in The Journal of Clinical Endocrinology & Metabolism.
Generic version of injectable acromegaly treatment launches in US

A generic version of a treatment for acromegaly is now available for adults in the U.S., according to an industry press release.
Cancer risk elevated for adults after Cushing’s syndrome diagnosis

Adults diagnosed with endogenous Cushing’s syndrome have a higher risk for developing cancer compared with controls without the condition, according to data published in the European Journal of Endocrinology.
Exposure to cholinergic compounds, personal care products may lead to early puberty

Some types of endocrine-disrupting chemicals may act as kisspeptin or gonadotropin-releasing hormone receptor agonists and could induce early puberty for children, according to in vitro findings published in Endocrinology.
Longer exposure to excess IGF-I levels may raise cancer risk for adults with acromegaly

Having high insulin-like growth factor I levels over a longer duration increased risk for cancer among adults with acromegaly, but not for those with nonfunction pituitary adenoma, according to study data.
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