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Bone/Mineral Metabolism News
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FDA approves two new biosimilars of denosumab
The FDA has approved two new biosimilars of denosumab to treat osteoporosis, increase bone mass, prevent skeletal-related events for people with multiple myeloma and other indications, Samsung Bioepis announced.
‘Alternative’ markers of insulin resistance can predict osteoarthritis
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Surrogate measures of insulin resistance, based on the triglyceride-glucose index, can be used to predict the development of osteoarthritis, according to data published in Scientific Reports.
About 31% of weight lost by adults during GLP-1 therapy comes from lean mass
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Lean mass constituted 30.8% of total body weight lost for adults who received a GLP-1 drug during a randomized controlled trial, according to findings published in Obesity.
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Endocrinology Drug and Device Update
In a review of the 2024 milestones, Healio | Endocrine Today compiled a list of drugs and devices related to the field that were newly approved, cleared or had label or indication changes. Information was gathered from the FDA website and news releases. We put our best effort into making a complete list and regret any omission. Appearance of a drug or device does not constitute any endorsement by Healio | Endocrine Today, its editors, publishers or editorial board. — The Editors
Zoledronate infusions every 5 years may lower fracture risk for early postmenopausal women
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Early postmenopausal women who receive zoledronate every 5 years have a lower risk for morphometric vertebral fractures than those receiving placebo, according to trial findings published in The New England Journal of Medicine.
Task force issues final recommendation on osteoporosis screening in older women
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In a final recommendation statement, the U.S. Preventive Services Task Force said that all women aged 65 years and older should be screened for osteoporosis to prevent fractures.
Lower fracture, higher cardiovascular risks seen with denosumab for patients on dialysis
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Among adults with osteoporosis on dialysis, use of denosumab significantly lowered fracture risk compared with bisphosphonate use, but cardiovascular risk was increased, according to study data.
Osteoporosis prevalence high for all races, incomes undergoing lung cancer screening
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Osteoporosis prevalence is high for patients undergoing lung cancer screening, regardless of race, ethnicity and income, but CT with AI detects osteoporosis and body composition without additional testing or radiation, researchers reported.
Sarcopenia unlikely for most after weight loss, but more data needed on older adults
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Most adults who lose weight as part of obesity therapy should not experience sarcopenia due to a decrease in fat-free mass, but more research is needed on the impact of GLP-1 receptor agonists and similar drugs on older adults.
Online patient groups helpful for women with pregnancy and lactation-induced osteoporosis
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Women with pregnancy and lactation-induced osteoporosis reported fewer disease-related fears or concerns after joining an online peer support group and sharing their health care experiences, researchers reported.
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