VIDEO: Subtyping, new mechanisms among hot topics in PCOS research
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BOSTON — In this video exclusive, Andrea Dunaif, MD, discusses some of the latest research on polycystic ovary syndrome featured at the ENDO 2024.
Dunaif is the Lillian and Henry M. Stratton Professor of Molecular Medicine at the Icahn School of Medicine at Mount Sinai and chief of the Hilda and J. Lester Gabrilove Division of Endocrinology, Diabetes and Bone Disease for the Mount Sinai Health System in New York, and a Healio | Endocrine Today co-editor.
Dunaif discusses new data on mechanisms of PCOS development. Women may have genetic markers that put them at greater risk for developing the syndrome. She describes how anti-Mullerian hormone can act on the hypothalamus and lead to high gonadotropin-releasing hormone levels.
Dunaif also talks about early data from an investigational anti-corticotropin-releasing hormone monoclonal antibody in development for the treatment of congenital adrenal hyperplasia and PCOS, as well as research she and her colleagues presented on PCOS subtyping. Researchers tested multiple clustering techniques to determine which one best identified clusters tied to genetic markers of PCOS.
“[PCOS] is really a multiple disorders,” Dunaif said. “If you use mathematical approaches like cluster analysis, you can show that there are distinct subtypes of PCOS. One has more reproductive features with higher luteinizing hormone [and] higher sex hormone binding globulin; one has more metabolic features with higher glucose, insulin and BMI. What’s really important is that these clusters, these subtypes are associated with different genetic markers.”
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