• 1. Appropriate management of a severe cetuximab infusion reaction should be:
• Your Colleagues Responded
• A. Stop infusion, when reaction stops, start at slower rate

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• B. Stop infusion, administer epinephrine, restart at same rate

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• C. Stop infusion, and mister benadryll, restart at lower rate

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• D. Stop infusion, permanently discontinue cetuximab and administer epinephrine, benadryll, steroids, and bronchodilators

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• 2. Your patient is receiving Peg-Interferon for melanoma and develops significant depression during the third month. Appropriate management is:
• Your Colleagues Responded
• A. Permanently discontinue interferon, refer to psychiatry/supportive care

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• B. Start SSRI, continue therapy

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• C. Stop interferon, and when recovered, restart at 33% dose reduction

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• D. Stop interferon, start SSRI, and when recovered restart at 33% dose reduction

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• 3. Appropriate management of Gr3 diarrhea with ipilimumab
• Your Colleagues Responded
• A. Hold infusion, reinitiate at next scheduled dose

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• B. Reduce dose by 33%

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• C. Permanently discontinue and give 1 mg/kg steroids over one month

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• D. Give 1 mg/kg prednisone over one month and restart infusions when recovered

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• 4. The commonest side effect on Pd-1 blockade aone is:
• Your Colleagues Responded
• A. Rash

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• B. Arthralgias

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• C. Diarrhea

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• D. LFT elevation

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• 5. PD-L1 blockade with atezolizumab is known to cause multiple side effects similar to other checkpoint inhibitors. Which side effect increases in importance when PD-L1 is blocked in comparison to PD-1?
• Your Colleagues Responded
• A. Rash

  0%
• B. Arthralgias

  0%
• C. Diarrhea

  0%
• D. pneumonitis

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