November 29, 2022
47 min listen
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Sponsored Episode: A Practical Approach to Diagnosing Hereditary Fever Disorders
The following podcast is sponsored by Novartis Pharmaceuticals Corporation.
In this Healio Rheuminations podcast episode, Hal Hoffman, MD, professor and chief of the Division of Pediatric Allergy, Immunology, and Rheumatology at the University of California, San Diego and Rady Children's Hospital of San Diego, joins host Adam J. Brown, MD, to discuss a practical approach to diagnosing autoinflammatory conditions. Listen as they discuss hereditary fever disorders and appropriate workup for diagnosis.
Key Takeaways:
- Autoimmunity occurs in classic autoinflammatory disorders including interleukin-1 mediated disorders, type I interferonopathies and NF-kappa-B tumor necrosis factor mediated disorders.
- Patient history of symptoms can guide diagnosis using pattern recognition, but many patients do not have a classic history that fits a particular diagnosis.
- Typical length of episode can be helpful to differentiate between the hereditary recurrent fever disorders.
- In classic hereditary fever disorders, with chronic inflammation, patients have chronically elevated serum amyloid A levels in the blood.
- Most periodic fever disorders should be considered recurrent fever disorders instead because they happen with some degree of consistency/frequency.
References:
Kastner DL. Hematology Am Soc Hematol Educ Program. 2005;74-81.
Bradley JR. J Pathol. 2008;214:149-160.
Webster JD, Vucic D. Front Cell Dev Biol. 2020;8:365.
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