The Complement System for Dunces

ByAdam J. Brown, MD

Here I break down the confusing system that is the ire of medical learners who aim to memorize it, only to forget it later. Join me on a medieval journey that will help you visualize this complex system in a way that will stay with you.

Brought to you by GSK. Consider the long-term impact of disease activity flares and corticosteroid use on patients with active SLE. Learn more now at treatfortodayandtomorrow.com.

Intro :10
Welcome :24
How do you explain the complement system? :44
What is the complement system? 1:39
How does it complement the adaptive immunity? 3:43
Two major aspects of the complement system 4:50
Formation of the membrane attack complex 5:21
Why is this pathway so confusing? 5:55
Why do I have to memorize all of this? 8:33
Let’s talk about the cascades themselves 11:15
Breaking down the three pathways 12:55

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The alternative pathway – walking to the beat of its own drum 16:15
A medieval tale of the classic and lectin pathway 22:36
The tale of the alternative pathway 28:00
Summary 31:55
In the next episode 32:40

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

References:

Music: The Medieval Banquet by Shane Ivers - https://www.silvermansound.com

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Sources/Disclosures

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Disclosures: Brown reports no relevant financial disclosures.

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The Complement System for Dunces

Healio Rheuminations

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