Women who consume more alcohol exhibit higher risk for OA-related hip replacement
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Key takeaways:
- Among women, those who drank more alcohol were more likely to undergo total hip replacement, in a dose-dependent manner, due to osteoarthritis.
- Outcomes did not depend on the type of alcohol.
Women who report higher levels of alcohol consumption are more likely to undergo a total joint replacement due to osteoarthritis, according to data published in Arthritis & Rheumatology.
“Alcohol consumption has been studied in several prospective cohort and case-control studies of women and no statistically significant relationship with hip OA has been observed,” Natalie E. Marchand, ScD, of the department of nutrition at the Harvard University T.H. Chan School of Public Health, in Boston, and colleagues wrote. “In general, moderate alcohol consumption has been associated with beneficial and adverse health outcomes.”
To investigate the connection between alcohol consumption and OA-related total hip replacements in women, Marchand and colleagues analyzed the Nurses’ Health Study, a prospective cohort initiated in 1976 that includes women in the nursing profession aged 30 to 55 years. Participants provided regular updates regarding diet, health and lifestyle. Meanwhile, alcohol consumption was reported every 4 years beginning in 1980.
Marchand and colleagues excluded patients if they underwent a hip replacement surgery before 1990, reported alcohol consumption of more than 100 grams per day, reported smoking more than 100 packs of cigarettes per year or did not complete the dietary survey. Patients who were enrolled after the initial questionnaire were added to the analysis if they met the analysis requirements.
Patients who reported undergoing a hip replacement procedure between June 1988 and May 1990 or after June 1, 1990, were included. Patients reporting earlier procedures were excluded because of the uncertainty of the procedure date. Patients were asked how many alcoholic beverages — consisting of a glass of wine; glass, can or bottle of beer; or shot — they consumed per day, week and month. Consumption categories ranged from zero drinks per month to six or more per day.
The analysis included 83,383 women without an OA diagnoses as of 1988, who were followed through June 2012. Compared with nondrinkers, patients who consumed alcohol demonstrated increasing hazard ratios for the development of hip OA, according to the researchers. Multivariable HRs were 1.04 (95% CI, 0.9-1.19) for patients who drank more than zero but fewer than 5 grams of alcohol per day, 1.12 (95% CI, 0.94-1.33) for those drinking 5 grams to 10 grams per day, 1.31 (95% CI, 1.09-1.64) for those who consumed 10 grams to 19 grams per day, and 1.34 (95% CI, 1.09-1.64) for those who drank up to 20 grams per day.
HRs remained similar regardless of the participants’ drink of choice, the researchers wrote.
“Greater alcohol consumption was associated with higher risk of total hip replacement due to hip OA in a dose-dependent manner,” Marchand and colleagues wrote. “An increase in risk was seen with intake of approximately one drink per day, and was not confined to any single type of alcoholic beverage.”
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