AWIR 2nd Annual Immunology Bootcamp Part 1: TNF and IL-6 Biology and Inhibitors

Chronic inflammatory diseases, such as rheumatoid arthritis, psoriasis, psoriatic arthritis, vasculitis and axial spondyloarthritis, represent a group of clinically heterogenous disorders that share a similar immunopathology. Untreated immune-mediated inflammatory diseases (IMIDs) can lead to devastating consequences. This educational activity, led by an expert rheumatologist, addresses the underlying pathogenesis of IMIDs and the utilization of TNF and IL-6 inhibitors.

Pretest:

1. Which of the following is not an effect of TNF in the pathogenesis of rheumatoid arthritis?

A. Activates B-cells to produce antibodies directed against cartilage.
B. Activates monocytes to secrete IL-1.
C. Activates synovial fibroblasts to secrete IL-6.
D. Activates endothelial cells to produce surface adhesion molecules.

2. For which of the following rheumatologic conditions is sarilumab approved?

A. Psoriasis.
B. Temporal Arteritis.
C. Sarcoidosis.
D. Rheumatoid Arthritis.

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Learning Objectives:

Upon completion of this educational activity, participants should be better able to:

• Examine the underlying pathology of chronic immune-mediated inflammatory conditions and resulting clinical implications.
• Review the immunological targets of available and emerging immune-based therapies.
• Select treatment for patients with IMID based on the latest clinical evidence and patient characteristics.

Overview

Author(s)/Faculty: Leonard H. Calabrese, DO; Jeffrey L. Kaine, MD; John R. P. Tesser, MD; Grace C. Wright, MD, PhD, FACR
Source: Healio Rheumatology Education Lab
Type: Lecture
Articles/Items: 5
Release Date: 10/11/2018
Expiration Date: 10/10/2019
Credit Type: ABIM MOC / CME
Number of Credits: 0.5
Cost: Free
Providers: Vindico Medical Education

CME Information

Provider Statement: This continuing medical education activity is provided by Vindico Medical Education.
Support Statement: This continuing medical education activity is provided by Vindico Medical Education.
Target Audience: The intended audience for this activity is rheumatologists and other health care professionals involved in the treatment of patients with rheumatoid arthritis (RA) and other chronic inflammatory conditions.