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Different molecular weights of HA yielded similar outcomes for delay of surgery for knee OA
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Results published in The Journal of Arthroplasty showed patients with knee osteoarthritis who received either low-, moderate- or high-molecular-weight hyaluronic acid injections had no significant differences in the likelihood of surgical interventions.
Using LifeLink Plus claims data from 2006 to 2015, researchers identified 30,417 patients with knee OA who received either low-, moderate- or high-molecular-weight hyaluronic acid (HA) injections. The primary outcome measure was all surgical interventions of the knee, and secondary outcome measures included any patient who underwent unicompartmental knee arthroplasty, total knee arthroplasty or TKA only.
Before adjusting for any confounders, investigators found patients who received low- and moderate-molecular-weight HA had a significantly lower likelihood of composite surgical events and TKA vs. patients who received high-molecular-weight HA. However, when use of low- and moderate-molecular-weight HA was matched with use of high-molecular-weight HA using the high-dimensional propensity score and inverse probability weighting, researchers found the difference in likelihood of composite surgical events and TKA disappeared. – by Casey Tingle
Disclosures: Shewale reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.
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