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Sufficient vitamin K, vitamin D yielded better lower extremity function in patients with knee OA
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Results published in Arthritis Care & Research showed patients with knee osteoarthritis who had sufficient vitamin K and vitamin D status experienced better lower extremity function.
Researchers measured baseline vitamin K and vitamin D levels and assessed lower extremity function using the short physical performance battery and 20-meter gait speed among 1,069 patients in the Health, Aging and Body Composition Study (Health ABC) Knee OA Sub-study. A replication analysis was performed using 4,475 participants in the Osteoarthritis Initiative. Researchers used the food frequency questionnaire to assess nutrient intake and assessed lower extremity function using the 20-meter gait speed and chair stand completion time.
During 4 years to 5 years, results showed overall better Health ABC physical performance battery and short physical performance battery, as well as faster 20-meter gait speed among participants with sufficient vitamin K combined with sufficient vitamin D at baseline in the Health ABC Knee OA Sub-study. Researchers also found overall faster 20-meter gait speed, chair stand completion time and 400-meter walk time among participants in the Osteoarthritis Initiative who had sufficient intake of vitamin K combined with sufficient intake of vitamin D at baseline. Although the change in 20-meter gait speed and chair stand completion time during follow-up differed according to vitamin K-vitamin D intake, results showed no difference in the change in 400-meter walk time. – by Casey Tingle
Disclosures : Please see the full study for a list of all other authors’ relevant financial disclosures.
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