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Poor Sleep Quality is a Feature of Psoriatic Disease
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Among patients with psoriatic disease, poor sleep quality was prevalent and associated with fatigue, anxiety and lower EuroQol-5D scores, according to findings.
esearchers evaluated consecutive patients seen Toronto Western Hospital’s treatment center for psoriatic arthritis (PsA n=113) and for psoriasis without psoriatic arthritis (PsC, n=62) during the course of 3 months. Additionally, they recruited 52 controls from a pool of healthy volunteers who had agreed to participate in the parent International Psoriasis and Arthritis Research Team (IPART) study.
Researchers collected baseline demographic information and complete medical history, and updated this data every 6 months to 12 months. At each visit, patients underwent a physical examination that determined the number of actively inflamed joints and the number of deformed joints attributable to joint damage instead of inflammation. They were also evaluated for fibromyalgia. Patients with PsC were assessed at 12-month intervals.
Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI. Additionally, patient-reported outcomes were collected, including the health assessment questionnaire (HAQ), dermatology life quality index, EuroQol-5D (EQ-5D), medical outcomes study short form-36 survey, patient’s global assessment, and the functional assessment of chronic illness therapy-fatigue (FACIT-fatigue) scale.
Researchers found the following rates of poor sleep quality in the groups of patients: PsA, 84%; PsC, 69%; and HC 50%. Both patients with PsA and those with PsC had higher total PSQI vs. HC and patients with PsA had higher PSQI scores vs. those with PsC. Patients with psoriatic disease (PsD) had lower mean EQ-5D scores vs. HC. Patients with PsD also had lower mean FACIT-fatigue scores vs. HC. Independent correlations were observed between worse PSQI and the following patient-reported outcomes: EQ-5D anxiety component, EQ-5D final and FACIT-Fatigue. These associations were observed in both PsC and PsA groups. In patients with PsA, an independent association was seen between actively inflamed (tender or swollen) joints and worse PSQI.
“Poor sleep quality is known to affect workplace productivity, mental health, health behaviors and perceived health,” the researchers wrote. “Ultimately, psoriatic disease is not simply a disease with only physical manifestations, but also a disease with psychosocial consequences,” the researchers wrote. “The multifactorial characteristics and extensive deleterious effects of PsD necessitate care from a multidisciplinary team to address all aspects of the disease.” -by Jennifer Byrne
Disclosures: The researchers report no relevant disclosures.
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