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Increased incidence of cancer seen in patients with pediatric-onset SLE
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During an average follow-up of 7.6 years, investigators found an increase in cancer rates among patients with pediatric-onset systemic lupus erythematosus compared to the general population; however, the incidence of cancer was still rare among these patients.
Researchers examined data from 12 pediatric systemic lupus erythematosus registries and identified 1,168 patients. Investigators determined the expected number of malignancies by multiplying person-years within the cohort by the geographically matched age-, sex- and calendar year-cancer rates and then adding the overall person-years. The standardized incidence ratio was developed with 95% CI for overall and hematologic malignancies.
Results showed 14 invasive cancers. Of these, three were hematologic. The standardized incidence ratio for hematologic cancers was 4.68. Investigators noted for both male and female patients for all age groups, there was an increase in the standardized incidence ratio. – by Monica Jaramillo
Disclosure: The study was funded by grants from the Canadian Institutes of Health MOP-106431 and the NIH 5R03CA149970-2.
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Bernatsky S, et al.J Rheumatol. 2017;doi:10.3899/jrheum.170179.
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