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Results support patient-reported outcomes measure for rheumatic conditions
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The 29-item Patient-Reported Outcomes Measurement Information System Profile, or PROMIS-29, with 4-item static forms showed some validity for measuring rheumatic conditions, according to published study results.
Researchers used data from the National Data Bank for rheumatic diseases in which participants completed PROMIS-29. This included 4-item forms for seven PROMIS domains.
There were 4,346 participants with rheumatoid arthritis, 727 with osteoarthritis, 241 with fibromyalgia and 240 with systemic lupus erythematosus. Participants in all groups were older (mean age range, 58-69 years), predominantly female, white and well-educated, with a mean disease duration of at least 20 years.
Subscales for physical function ad pain interference had large ceiling effects in the RA, OA and SLE cohorts.
“Correlation of PROMIS-29 scores with scales measuring similar constructs ranged from high to moderate for RA, OA and SLE; correlations for [fibromyalgia] were markedly lower for some scales,” the researchers wrote.
Increasing disease severity or declining health status were related to consistent patterns of worsening PROMIS-29 scores.
The questionnaire was completed by 60% of respondents online and 39% by mailed paper questionnaire. There were differences in scores in online compared with paper questionnaires, with a range of 0.3 to 2.2 points.
“Previous studies of PROMIS scales in rheumatology have focused on the [computer adaptive testing] versions of the scales or on longer static forms,” the researchers wrote. “This article presents the first analysis of the PROMIS-29 in RA, OA, [fibromyalgia] and SLE,” the researchers wrote.
“Our results provide guarded support for the validity of the PROMIS-29 in these rheumatic conditions,” the researchers concluded. “The 4-item static forms included in the PROMIS-29 appear to identify differences among individuals at different levels of health, and to be measuring constructs similar to those measured by legacy questionnaires. However, measurement appears to be more precise at the ‘bad’ ends of the scale, as evidenced by the large ceiling effects of some of the scales. Future work will need to determine if these ceiling effects exists in other samples and if they have an impact on the responsiveness of the PROMIS-29 scores.” – by Bruce Thiel
Disclosures: The authors report no relevant financial disclosures.
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