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Structural damage showed implications for physical function in patients with PsA
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Among patients with psoriatic arthritis, structural damage impacted physical function, according to a recently published study.
“[Our] results reveal that responsiveness of functional limitations decreases with increasing joint damage,” the researchers wrote. “They further suggest that — similar to what has been shown in rheumatoid arthritis (RA) — [joint space narrowing] is functionally more important than [erosions] ERO.”
Investigators assessed 363 patients who were enrolled in the GO-REVEAL study and had been assessed after 24 weeks, 52 weeks and 104 weeks. For disease activity-adjusted models that used total modified Sharp/van der Heijde scores (mSvdHS), joint space narrowing (JSN) and ERO, as well as in the remission analyses for mSvdHS and JSN, the researchers found an effect of damage on function. In addition, they found functional responsiveness was limited by increasing total mSvdHS, JSN and ERO.
“Both achievable [health assessment questionnaire] HAQ levels and HAQ responses are negatively impacted by a high degree of structural damage,” the researchers wrote. “Consideration of these components is clinically and therapeutically relevant, as the HAQ component related to inflammation is expected to be reversible, while the component related to destructive changes is not.” – by Will Offit
Disclosures: The researchers report no relevant financial disclosures.
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