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Multimodal knee OA treatment program with sodium hyaluronate injections seen as cost-effective
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Investigators found an 8-week multimodal treatment program for patients with knee osteoarthritis that included a cycle of intra-articular injections of sodium hyaluronate administered weekly was cost-effective and reduced patient symptoms.
Researchers performed a telephone interview with 218 patients who were part of a 8-week multimodal knee osteoarthritis treatment program. The mean follow-up was 3.7 years. The program included physical therapy, knee bracing, patient education and five intra-articular knee injections of sodium hyaluronate.
Knee pain severity, WOMAC subscores, current medication use and history of total knee arthroplasty (TKA) were assessed in all patients. The incremental cost-effectiveness ratio (ICER) of the treatment group was determined with base-case analyses, subgroup analyses and sensitivity analyses and compared with controls who underwent standard care and had results published in the literature.
Results showed a 60% decrease in knee pain severity and WOMAC subscores decreased 33% to 42% vs. baseline scores. During follow-up, 22.8% of knees underwent TKA. Compared with usual care, the treatment program had a base-case ICER of $6,000 per quality-adjusted life year (QALY).
According to researchers, ICERs ranged from $3,996 to $10,49 per QALY for subgroup analyses, sensitivity analyses and probabilistic sensitivity analyses. The $50,000, $100,000 and $150,000 per QALY thresholds had 97.2%, 98.9% and 99.4% ICER below willingness-to-pay limits, respectively. – by Monica Jaramillo
Disclosures: Miller reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.
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