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Radiographic knee OA linked with increased risk for premature death
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LAS VEGAS — According to a presenter here, patients with symptomatic radiographic knee osteoarthritis had a 19% increased risk for premature death compared with osteoarthritis-free participants.
Kirsten M. Leyland, MSc, DPhil, from the Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford, and colleagues assessed six population-based cohorts and one enhanced risk factor cohort. Of the cohorts, three were from the United States; one was from the United Kingdom; one was from the Netherlands; and one was from Australia. Of the patients selected for the study, none had rheumatoid arthritis and they were aged between 45 years and 80 years. In total, there were 9,889 subjects with a median follow-up between 5.6 years and 19.8 years.
Overall, investigators found an increased risk for premature mortality in patients with symptomatic radiographic knee osteoarthritis (ratio= 1.19), after adjustment for age, gender and ethnicity. However, there was no increased risk for patients with symptomatic non-radiographic knee osteoarthritis. – by Will A. Offit
Reference:
Leyland KM, et al. Paper #31. Presented at: Osteoarthritis Research Society International World Congress; April 27-30, 2017; Las Vegas.
Disclosure: Leyland reports no relevant financial disclosures.