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Psoriatic arthritis was associated with osteoporosis, ankylosing spondylitis
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Investigators of this cross-sectional study found psoriasis and psoriatic arthritis correlated with pathologic fractures and other bone-related conditions.
Johnathan I. Silverberg , MD, PhD, MPH, in the Department of Dermatology at Northwestern University Feinberg School of Medicine, and colleagues studied 198,102,435 children and adults with information in the National Emergency Department Sample. Of these, 183,725 patients were diagnosed with psoriasis and 28,765 patients diagnosed with psoriatic arthritis during emergency department visits between 2006 and 2012.
Researchers found patients with psoriasis had significantly higher odds of being diagnosed with osteopenia (ratio = 2.86), osteoporosis (ratio = 2.97) and osteomalacia (ratio = 4.4). They also had higher odds of ankylosing spondylitis (ratio = 13.34) and pathological fractures (ratio = 2.35), as well as vertebral (ratio = 1.17), pelvic (ratio = 1.18), femoral (ratio = 1.68) and tibial/fibular fractures (ratio = 1.28).
Patients with psoriatic arthritis also had significantly higher odds of being diagnosed with osteopenia (ratio = 4.13), osteoporosis (ratio = 4.04), osteomalacia (ratio = 10.95), ankylosing spondylitis (ratio = 48.21) and pathological fractures (ratio = 3.41). Investigators found these patients also had higher odds for stress fractures (ratio = 2.87), vertebral fractures (ratio = 1.45) and pelvic fractures (ratio = 1.75). They were also associated with femoral fractures (ratio = 2.07) and tibial/fibular fractures (ratio = 1.6). – by Will Offit
Disclosure: The researchers report funding by a grant from the Agency for Healthcare Research and Quality and the Dermatology Foundation.
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