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Diabetes, high BMI linked with increased mortality risk for patients with hip OA

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WASHINGTON — The relationship between hip osteoarthritis and mortality was increased among patients with diabetes as well as a higher BMI at baseline, according to findings presented at the American College of Rheumatology Annual Meeting.

“The idea that [osteoarthritis] OA may lead to premature death is not new,” Rebecca Cleveland, PhD, professor of medicine at the University of North Carolina, said during her presentation. “Back in the early ‘70s, studies have found that hip OA and knee OA both led to premature death. Since then, there has been a growing body of evidence that has looked at the association between OA and subsequent death.”

Cleveland and colleagues analyzed data from the Johnston County Osteoarthritis Project to determine the association between baseline hip radiographic OA (rOA) and all-cause mortality, stratified by diabetes and BMI. The cohort included 2,381 patients with hip radiographs, including a group that had its baseline assessment between 1990 and 1997 (n = 1,817) and a group that had its assessment between 2003 and 2004 (n = 564). Of the patients, the mean age was 61.1 years and the average follow-up was 14.2 years. Overall, 55.9% were women; 31.5% were African-American; 23.8% were smokers; 12% had diabetes; and 33.4% had a BMI of at least 30 kg/m². The researchers defined hip rOA as a Kellgren-Lawrence grade of at least 2 in either hip. They defined symptomatic rOA (sxOA) as a subset of patients who had symptoms of pain in that joint.

The researchers found those with diabetes and hip rOA were 45% more likely to die than those without OA. However, there was no association between hip rOA and death among patients without diabetes. The results were similar for sxOA. In addition, patients with a BMI of at least 30 and hip sxOA were 50% more likely to die than those without OA; whereas, there was no association between hip sxOA and death among patients with a BMI of less than 30. – by Will Offit

Reference:

Cleveland R, et al. Abstract #3047. Presented at: American College of Rheumatology Annual Meeting; Nov. 11-16, 2016; Washington.

Disclosure: The researchers report no relevant financial disclosures.