October 11, 2016
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Cam deformity, acetabular dysplasia associated with hip OA

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Cam deformity and acetabular dysplasia were associated hip osteoarthritis, according to a recently published study.

“The association between hip deformity and the development of osteoarthritis (OA) has been debated in the orthopedic community for many decades,” Young-Jo Kim, MD, PhD, professor of orthopedic surgery at Harvard Medical school, wrote in a related editorial on the study. He added, “[It] seemed clear that pistol grip deformities are associated with OA, but it was not clear if pistol grip deformity is a cause rather than a reaction to OA.”

To verify these associations, Fatemeh S. Hosnijeh, MD, PhD, and colleagues from the Netherlands performed an analysis of the Rotterdam study cohort, which included 4,438 participants without OA at baseline. The average follow-up was 9.2 years. OA was defined as a Kellgren and Lawrence grade of at least 2 or a total hip replacement at follow-up. Cam deformity was determined by alpha angles, and acetabular dysplasia as well as pincer deformity were each determined by center-edge angles. Researchers calculated odds ratios to assess the associations.

They found an increased risk for hip OA for both cam deformity (odds ratio = 2.11) and acetabular dysplasia (odds ratio = 2.19). There was no association found for pincer deformity. According to the stratification analyses, these associations were each driven by younger age groups, while BMI had no effect. Female gender also drove the association for acetabular dysplasia.

“Now the question remains how we should incorporate this growing body of evidence linking hip deformity and early OA,” Kim wrote. “At present, rapid advances are being made in both open and arthroscopic surgical techniques for hip deformity correction and intra-articular damage repair. Currently, treatment is geared towards symptom modification only. Should we start to contemplate treatment for disease modification as well, ie prophylactic treatment? What is the cause of these morphologic variations and what factors contribute to these deformities causing aging? Many important questions remain unanswered.” – by Will Offit

Disclosures: Hosnijeh and colleagues report no relevant financial disclosures. Healio.com/Rheumatology could not confirm Kim’s disclosures at the time of publication.