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Different subtypes of microparticle-containing immune complexes found in patients with SLE
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Patients with systemic lupus erythematosus had different subtypes of microparticle-containing immune complexes that were associated with distinct clinical characteristics, including disease activity and vascular damage, recently published results showed.
Using flow cytometry in plasma of 191 women with systemic lupus erythematosus (SLE), researchers quantified microparticles expressing surface immunoglobulin G, platelet antigen (CD41+) and phosphatidylserine. Overall, 113 patients underwent carotid ultrasound. Through Spearman correlation analysis, researchers analyzed whether levels of microparticles were associated with SLE disease activity index 2000 (SLEDAI-2K), Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SDI) and carotid ultrasound plaques and intima-media thickness (CIMT) as surrogates for vascular damage.
In patients with SLE, results showed the presence of CD41+ microparticles harboring immunoglobulin G. Researchers noted a positive correlation between SLEDAI-2K and levels of CD41+ microparticles harboring immunoglobulin G, as well as with exposing and non-exposing phosphatidylserine. Researchers also found concentrations of CD41– microparticles harboring immunoglobulin G and exposing phosphatidylserine were correlated with SDI and CIMT. According to results, LDL level, BMI and antimalarial drug use were independent of associations. – by Casey Tingle
Disclosure: The researchers report no relevant financial disclosures.
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