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Lower levels of residual inflammation seen on hand MRIs with use of ACR/EULAR vs DAS28 definitions
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Results from this study showed patients with rheumatoid arthritis who were in remission had lower levels of MRI-detected residual inflammation according to the Simplified Disease Activity Index and the Boolean American College of Rheumatology/EULAR criteria compared with DAS28 criteria.
Researchers performed a cross-sectional study of patients with rheumatoid arthritis (RA) who had different levels of disease activity. Investigators recorded data which included duration of RA, remission duration, treatment, positivity for rheumatoid factor and/or anticyclic citrullinated peptide antibodies. The DAS28, Simplified Disease Activity Index (SDAI) and Boolean American College of Rheumatology (ACR)/EULAR remission criteria were also calculated.
MRIs of the hand were used to determine the inflammation scores for bone marrow edema (BME), synovitis, tenosynovitis and total inflammation. Investigators used receiver-operating characteristic analysis to determine the best cutoff values that correlated with each inflammatory remission lesion on hand MRI.
Of the 388 hand MRIs, 130 were categorized as being in remission. Investigators noted the cutoff values correlated with remission using an SDAI of less than or equal to 3.3 and the definitions for BME and tenosynovitis according to the ACR/EULAR definitions were lower compared with the DAS28 definitions for BME and tenosynovitis of less than or equal to 2.6. Compared with DAS28 criteria, the median scores for synovitis, BME and total inflammation were lower using SDAI and Boolean ACR/EULAR criteria. ‒ by Monica Jaramillo
Disclosure: The study was supported by Pfizer Laboratories.
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