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Lesinurad plus allopurinol reduced serum urate levels in patients with gout
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Patients with gout treated with allopurinol plus lesinurad had reduced serum urate levels compared with allopurinol alone, according to results of a randomized, double-blind, placebo-controlled study.
Researchers studied 603 patients (94% men) with gout who were being treated with 300 mg or more allopurinol but had inadequate response to it, who had a serum urate level of 6.5 mg/dL or more and who had two or more gout flares in the prior year. They randomly assigned the patients to receive orally lesinurad 200 mg, lesinurad 400 mg or placebo that was added to the patients’ continued treatment with allopurinol. The proportion of patients per group who achieved serum urate levels less than 6 mg/dL by 6 months was considered the primary endpoint. Among the key secondary endpoints were a mean gout flare rate requiring treatment and the proportion of patients with complete resolution of one or more target tophi.
By 6 months, results showed a significantly increased proportion of patients in the lesinurad 200 mg (54.2%) and lesinurad 400 mg (59.2%) plus allopurinol groups achieved target serum urate levels compared to patients treated with allopurinol alone (27.9%). However, researchers found patients who received lesinurad plus allopurinol had rates of gout flares and tophus resolution completion that were similar those in patients who received allopurinol alone.
Except for higher incidences of predominantly-reversible serum creatinine elevation, lesinurad 200 mg plus allopurinol had a comparable safety profile to allopurinol alone and was generally well-tolerated, according to results. – by Casey Tingle
Disclosures: Saag received grant or research support from Ardea, Crealta and Takeda; and is a consultant for Ardea/AstraZeneca and Takeda. Please see the full study for a list of all other authors’ relevant financial disclosures.
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