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Worse survival rates seen in patients with systemic sclerosis/ polymyositis overlap vs systemic sclerosis
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The survival rate was worse for patients with systemic sclerosis/polymyositis overlap vs. systemic sclerosis, according to study results.
Researchers used the Nijmegen Systemic Sclerosis cohort to identify 396 patients with systemic sclerosis (SSc) and 24 patients with SSc/polymyositis (SSc-PM) overlap. Investigators determined the incidence rates using the number of deaths and time of follow-up. Cox proportional hazard model was used to conduct survival analysis and to compare survival rates between patients with SSc and patients with SSc-PM overlap.
Results showed that for patients with SSc, the 5-year and 10-year cumulative survival rates were 93% and 87%, respectively. For patients with SSc-PM overlap, these rates were 82% and 68%, respectively. Investigators noted the adjusted hazard ratio was 2.34 for SSc-PM overlap group vs. the SSc group, with confounders including age at diagnosis, modified Rodnan skin score, diffuse cutaneous subtype and male gender. For both patients with SSc-PM overlap and patients with SSc, the most common cause of death was cardiopulmonary involvement. ‒ by Monica Jaramillo
Disclosure: The researchers report no relevant financial disclosures.
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