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Study shows association between baseline patient characteristics, development of erosions in PsA cohort
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Recently published results showed an association between baseline patient characteristics and the development of erosions among patients with psoriatic arthritis.
Researchers analyzed radiographs of 290 patients with psoriatic arthritis and at least 10 years of follow-up in the Toronto Psoriatic Arthritis Cohort. With logistic regression models, investigators used baseline characteristics to predict the development of erosions.
Results showed 12.4% of patients were erosion-free and 87.6% of patients were erosion-present, with erosion-free patients diagnosed with psoriasis at a younger age. Researchers found actively inflamed joints in 93% of erosion-present patients at baseline and in 69.3% at last follow-up visit compared with 72% and 52.8% of erosion-free patients at those time points, respectively. Although erosion-present patients had a greater number of actively inflamed joints vs. erosion-free patients at baseline, results showed the two groups had a similar number of actively inflamed joints at last follow-up visit. According to results, 87.4% of erosion-present patients had clinically damaged joints at last follow-up vs. 27.8% of the erosion-free patients. A higher percentage of unemployment was found among erosion-present patients (52%) vs. erosion-free patients (25%), with higher unemployment rates found in erosion-present patients with upper and lower extremity involvement, researchers noted.
According to results of a univariate analysis, the development of erosions was associated with an actively inflamed joint count, damaged joint count and the use of disease-modifying antirheumatic drugs or nonsteroidal anti-inflammatory drugs. Multivariate analysis also showed actively inflamed joint count and damaged joint count were predictive of the development of erosions, but the odds of developing erosion decreased with a longer duration of psoriasis. – by Casey Tingle
Disclosures: Touma is supported by Great-West life, London Life and Canada Fellowship. Please see the full study for a list of all other authors’ relevant financial disclosures.
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