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Study links biomarkers of tissue inflammation to progression of OA
Concentrations of urinary type II collagen degradation and serum cartilage oligomeric protein correlated with the progression of osteoarthritis, according to study results. The study also confirmed matrix metalloproteinase-dependent degradation of C-reactive protein as a predictor for the risk of osteoarthritis progression apart from the established biomarkers.
Researchers measured the serum levels of tissue type I collagen turnover (C1M), matrix metalloproteinase-dependent degradation of C-reactive protein (CRPM) and cartilage oligomeric protein (COMP) and CRP in 1,335 patients from the population-based Rotterdam Study using enzyme-linked immunosorbent assay. They also detected urinary type II collagen degradation (uCTX-II).
Investigators assessed radiographs to score the stage of osteoarthritis (OA) at baseline and at 5-year follow-up using the Kellgren-Lawrence grade. Logistic regression analysis and generalized equations were adjusted for age, sex and BMI and were used to determine correlations between the progression and incidence of OA and the baseline biomarkers.
Results showed the incidence and progression of OA correlated with uCTX-II, COMP and CRP concentrations. At baseline, researchers noted that age-, gender- and BMI-adjusted data showed the biomarkers were associated with each other, “with the highest correlation between CRP, CRPM and C1M.”
Investigators noted OA progression positively correlated with CRPM and CRP levels, which were similar to the effect size of uCTX-II and COMP. CRPM was independent from uCTX-II and COMP, and had prognostic value for OA progression. ‒ by Monica Jaramillo
Disclosures: The study was funded by the Dutch Arthritis Foundation (project number 13-1-201) and the Netherlands Society for Scientific Research VIDI grant 917103521. The biomarker measurements were partly supported by the TreatOA consortium (FP7-HEALTH-2007-2.4.5-1) and the Danish Research Foundation.