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Top read articles about Sjögren’s syndrome highlight overlooked symptoms
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The most highly read articles on Healio.com/Rheumatology about recently published research into Sjögren’s syndrome focus on symptoms, such as pruritus, and patient subtypes related to disease activity. Techniques to identify patients at risk for high disease activity also were highlighted.
High incidence of pruritus found among patients with primary Sjögren’s syndrome
Patients with primary Sjögren’s syndrome may have a high incidence of pruritus that may negatively impact sleep and quality of life, according to recently presented data. Read more.
Patients with Sjögren’s syndrome and certain antibodies have greater disease activity
Disease activity was higher in patients with Sjögren’s syndrome who had certain autoantibodies; which were significantly associated with the presence of anti-Ro60, anti-Ro52, anti-La, rheumatoid factor and hypergammaglobulinemia; as well as higher ocular surface staining scores, lower Schirmer’s test scores and minor labial salivary gland biopsy focus scores of 3 or higher, according to recently published research. Read more.
Anti-centromere antibodies linked to subtype of patients with Sjögren’s syndrome
Although patients with Sjögren’s syndrome who had anti-centromere antibodies had more severe exocrine glandular dysfunction and more pronounced inflammation of the labial salivary glandular, this characteristic was not linked with fibrosis, according to researchers. Read more.
Invariant NKT cells found in peripheral blood, not salivary glands, of patients with primary Sjögren’s syndrome
Investigators of a recently published study found invariant natural killer T (NKT) cells ex vivo in the peripheral blood from patients with primary Sjögren’s syndrome, but not in their salivary glands, and detected anti-SSA-specific B cells in target tissue. Read more.
Higher fecal calprotectin levels linked to GI disease in patients with Sjögren’s syndrome
Patients with Sjögren’s syndrome and gastrointestinal (GI) disease were more likely to have elevated levels of fecal calprotectin compared to patients without GI disease, according to researchers from Sweden. Read more.
Vitamin D deficiency may not play a role in Sjögren’s syndrome
Patients with Sjögren’s syndrome tended to have higher levels of vitamin D compared with healthy control participants in a recently presented study, which found no association with antibodies and levels of vitamin D. Read more.