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Patients with entheses-related, undifferentiated JIA had lower PROs than children with other forms of JIA
Lower patient-reported outcomes were observed in patients with entheses-related and undifferentiated juvenile idiopathic arthritis compared to oligoarticular and polyarticular rheumatoid factor-negative and other forms of juvenile idiopathic arthritis, according to recently published data.
Researchers studied 398 patients with juvenile idiopathic arthritis (JIA) during 1,577 visits between June 2010 and December 2012 at the Children’s Hospital of Philadelphia in a retrospective, longitudinal cohort study. Subtypes of JIA were defined according to the International League of Associations for Rheumatology (ILAR) criteria in seven categories: oligoarticular (n = 451 visits), systemic (n = 91 visits), Rheumatoid factor (RF)-positive (n = 42 visits), RF-negative (n = 213 visits), psoriatic arthritis (PsA, n = 80 visits), entheses-related arthritis (ERA, N = 257 visits) and undifferentiated arthritis (n = 92 visits).
A significantly higher prevalence of moderate and severe pain was reported by patients with ERA, psoriatic and undifferentiated JIA. The lowest median pain intensity over the prior week was reported by patients with oligoarticular, systemic and polyarticular RF-negative JIA compared to the highest median pain intensity reported by patients with ERA and undifferentiated JIA. Multivariate models showed that the physician’s global disease activity assessment, female sex, NSAID and intra-articular glucocorticoid use were predictive of higher pain. No significant correlations was seen between the use of traditional or biologic disease modifying anti-rheumatic drugs (DMARDs).
A decreased quality of life in the 4 weeks prior to administration of the questionnaire was seen in children with ERA and PsA and the highest median value of decreased quality of life was seen in patients with undifferentiated JIA. No significant correlations was seen between the use of traditional or biologic DMARDs.
Decreased physical function including moderate-to-severe impairment in function was most often reported by children with polyarticular RF-positive, polyarticular RF-negative and ERA JIA. No significant correlations was seen between the use of traditional or biologic DMARDs. – by Shirley Pulawski
Disclosure: The researchers report no relevant financial disclosures.