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Bohan and Peter classification may lead to misdiagnosis of patients with myositis
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The use of Bohan and Peter classification criteria resulted in the misdiagnosis of patients with myositis, while more recently proposed Troyanov clinical-serological criteria were more accurate, according to researchers from the St. Ivan Rilski hospital in Sofia, Bulgaria.
A group of 95 adult patients with myositis were studied. Using Bohan and Peter criteria, 32% of the patients were diagnosed with polymyositis (PM), but using modified criteria, the number was reduced to 13.75%. The use of criteria proposed by Y. Troyanov, which includes detection of autoantibodies in blood sera, reduced the number of patients diagnosed with PM to 11.25%.
Dermatomyositis was diagnosed according to Bohan and Peter criteria in 25% of the patient cohort, but the number was reduced to 11.25% of patients with the use of modified criteria, and further reduced to 7.5% with the use of the clinical- and serological-based Troyanov criteria. Overlapping PM/DM was identified in 30% of the patients by Bohan and Peter criteria, but with the application of modified criteria, 63.75% of patients were diagnosed with overlap PM/DM and the use of Tryanov criteria identified 70% of patients with overlapping PM/DM.
“The original Bohan and Peter classification leads to misclassification of patients with myositis,” the researchers wrote. “It is necessary to use a novel approach to the classification of [autoimmune myositis], which based on the clinical features and immunological profile of the patients.” – by Shirley Pulawski
Reference:
Kalinova D, et al. Paper #AB0685. Presented at: European League Against Rheumatism Annual European Congress of Rheumatology. June 10-13, 2015; Rome.
Disclosure: The researchers report no relevant financial disclosures.