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No link found between serum uric acid, mean platelet volume and cognition in patients with FM
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Cognitive function was not associated with serum uric acid levels or mean platelet volume in patients with fibromyalgia, according to the details from a recently published study.
A group of 54 premenopausal women with fibromyalgia (FM) diagnosed according to the American College of Rheumatology criteria who attended the outpatient rheumatology clinic at the Baclar Training and Research Hospital in Istanbul were studied alongside 33 healthy participants matched for age and gender. No statistically significant differences were observed between the two groups.
Pain and sleep quality were assessed using a VAS, and functional status was evaluated using the Fibromyalgia Impact Questionnaire (FIQ). The Beck Depression Inventory (BDI) was used to assess psychological status, and the Mini Mental State Examination (MMSE) was used to evaluate the frequency of cognitive impairment. Serological assessments included measurements of mean platelet volume (MPV), platelet counts and serum uric acid (UA) levels.
The mean VAS for pain and sleep quality was significantly higher in patients with FM compared with individuals in the control group, and significant differences in FIQ and BDI scores between groups, according to the researchers. Patients with FM had significantly lower MMSE scores, but no significant differences were observed with MPV, platelet counts or serum UA between the two groups.
No significant correlations were observed between serum UA or MPV levels and VAS for pain or sleep quality, FIQ, BDI or MMSE scores, the researchers reported. – by Shirley Pulawski
Reference:
Vural M, et al. Paper #AB0946. Presented at: European League Against Rheumatism Annual European Congress of Rheumatology; June 10-13, 2015; Rome.
Disclosure: The researchers report no relevant financial disclosures.