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Patients with RA, PsA, AS more likely to have low vitamin D

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Patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis were more likely to have vitamin D deficiency than matched individuals without any of the three diseases, according to research presented at the European League Against Rheumatism Annual European Congress of Rheumatology.

The study group comprised 775 patients with rheumatoid arthritis (RA), 738 patients with ankylosing spondylitis (AS) and 721 patients with psoriatic arthritis (PsA) enrolled in the Cardiovascular in Rheumatology (CARMA) study, a 10-year prospective study from 67 hospitals in Spain.

The 2,234 patients were matched to 677 unexposed participants. Median vitamin D levels were 20.4 ng/mL in patients with RA, 20.9 ng/mL in patients and 20 ng/mL in patients with PsA compared with 24.8 ng/mL in unexposed participants. The researchers observed vitamin D deficiency in 40.5% of patients with RA, 39.7% of patients with AS and in 40.9% of patients with PsA compared with a 26.7% deficiency present in unexposed participants, with an odds ratio of 2.28 for the three patients groups patients with chronic inflammatory disease.

Vitamin D deficiency in patients with RA, AS and PsA was significantly associated with the presence of anti-cyclic citrullinated peptide antibodies in patients with RA and in the Bath Ankylosing Spondylitis Functional Index in patients with AS. No other associations were observed, according to the researchers. – by Shirley Pulawski

Reference:

Urruticoechea Arana A, et al. Paper #AB0148. Presented at: European League Against Rheumatism Annual European Congress of Rheumatology; June 10-13, 2015; Rome.

Disclosures: Urruticoechea Arana reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.