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Researchers find BCSI to be useful for study of Sjögren’s syndrome cognitive symptoms
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The Brief Cognitive Symptoms Inventory was found to be a useful tool for the study of cognitive symptoms in patients with Sjögren’s syndrome, according to study results.
One hundred and forty-four patients who met the American-European Consensus Group criteria for Sjögren’s syndrome and 35 healthy controls completed a questionnaire assessing symptoms including cognitive complaints. Researchers calculated Cronbach’s alpha to assess internal consistency and Pearson correlation coefficients to test for associations between the Brief Cognitive Symptoms Inventory (BCSI), symptoms and demographic variables. To establish cutoff criteria for the differentiation of case versus non-case, the researchers analyzed total score distribution.
Neuropsychological outcomes of patients with Sjögren’s syndrome above the threshold BCSI score were compared with neuropsychological outcomes below the threshold to assess the association of cognitive symptoms with objective cognitive deficits.
Study results showed good internal consistency of the BCSI, with similar scores in all patient groups. However, compared with controls, patients reported more cognitive symptoms. The researchers also found a moderate correlation with BCSI scores and pain, depression, anxiety, fatigue and healthy quality.
Twenty percent of patients with Sjögren’s syndrome reported high scores for cognitive dysfunction vs. 3% of controls. Patients with cognitive scores greater than 50 experienced more depression, fatigue, pain and worse performance on multiple cognitive domains, according to the researchers.
Disclosure: This research was supported by the U.S. National Institutes of Health R01AR50782.
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