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Higher rates of VTE found among patients with inflammatory rheumatologic diseases
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Patients with inflammatory rheumatologic diseases experienced rates of venous thromboembolism more than three-times higher than the general population, according to study results.
Researchers searched PubMed, Embase, Cochrane Databases and Medline and identified 25 studies related to rheumatologic inflammatory diseases and venous thromboembolism (VTE). The researchers extracted data regarding rates of deep vein thrombosis (DVT) and pulmonary embolisms (PEs) and compared pooled estimates for VTE in individual and pooled diseases with matched populations using random effects models.
Compared with an age- and sex-matched population, the researchers found 10 studies that included 5,273,942 rheumatoid arthritis-identified patients and 891,530,181 controls, with a cumulative incidence of 2.18% and an odds ratio of 2.23.
Study results also showed a cumulative incidence of 7.29% in 54,697 patients with systemic lupus erythematosus. Four studies of patients with Sjogren’s syndrome demonstrated a VTE cumulative incidence of 2.18%, and four studies of patients with inflammatory myositis showed a VTE cumulative incidence of 4.03%.
Rates of systemic sclerosis were 3.13%, and rates of anti-neutrophil cytoplasmic antibody vasculitis was 7.97%, according to the researchers.
Disclosure: The authors have no relevant financial disclosures.
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