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No association found between hand osteoarthritis, serum leptin
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A cross-sectional analysis of a large US cohort found no evidence that serum leptin is associated with hand osteoarthritis, according to recent data.
The Third National Health and Nutrition Examination Survey (NHANES III), along with established classification criteria of hand osteoarthritis (OA), were used to estimate unadjusted mean serum leptin concentrations by hand OA status. Potential confounders included sex, BMI, presence of polyarticular OA, diabetes and total cholesterol.
Researchers developed a linear regression model to assess mean leptin levels adjusted for appropriate confounders. NHANES III patients who had a hand exam and a leptin measurement (n=1,056) were analyzed. No significant differences in mean serum leptin levels were found (unadjusted analysis) in patients with:
Symptomatic hand OA:
- 7.38 ng/mL in males (95% CI, 5.31-9.46)
- 21.55 ng/mL in females (95% CI, 17.08-26.02)
Asymptomatic hand OA:
- 6.69 ng/mL in males (95% CI, 5.19-8.18)
- 17.09 ng/mL in females (95% CI, 15.00-19.18)
No hand OA:
- 8.22 ng/mL in males (95% CI, 7.47-8.97)
- 20.77 ng/mL in females (95% CI, 18.01-23.53)
“In a multivariable linear regression model that included variables of hand OA status, age, race/ethnicity, and obesity status, we found no statistically significant association between serum leptin and hand OA status,” the study authors wrote.
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