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PET/CT scans, using bone tracer, reflected ankylosing spondylitis
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PET/CT data, used with the bone tracer [18F]Fluoride, demonstrated that bone formation rather than inflammation better depicts ankylosing spondylitis, according to recent study results.
Researchers tested the efficacies of specific PET/CT with inflammation tracers, such as [18F]FDG and [11C](R)PK11195. They also tested PET/CT and [18F]Fluoride, as well as an MRI scan, to visualize ankylosing spondylitis in 12 patients aged 18 to 70 years. Eligible patients fulfilled the modified New York criteria. The patients were categorized as low disease activity (n=5) or high disease activity (n=7) as determined by the Bath Ankylosing Spondylitis Disease Activity Index.
Study results showed no significant visualizations in the PET/CT tracers of [18F]FDG or [11C](R)PK11195. MRI results, however, revealed five bone edema lesions in three of 10 patients, and the [18F]Fluoride PET/CT that was used for two patients revealed 17 regions with increased uptake in vertebral column ad sacroiliac joints.
“Our PET/CT data suggest that ankylosing spondylitis activity is reflected by bone activity [formation] rather than inflammation,” the researchers said. “The results also show the potential value of PET/CT for imaging ankylosing spondylitis activity using the bone tracer [18F]Fluoride. In contrast to active rheumatoid arthritis, inflammation tracers [18F]FDG and [11C](R)PK11195 appeared to be less useful for ankylosing spondylitis imaging.”
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