Treatment patterns for metastatic long-bone disease had varying effects on survivorship
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Key takeaways:
- Patients who underwent surgery for metastatic long-bone disease had increased survival with use of checkpoint inhibitors for targeted therapy.
- However, chemotherapy was associated with worse overall survival.
SAN FRANCISCO — Results presented at the American Academy of Orthopaedic Surgeons Annual Meeting showed different treatment patterns for metastatic long-bone disease had varying effects on patient survivorship.
Michelle R. Shimizu, BS, and colleagues retrospectively reviewed data on 1,495 patients who underwent surgery for metastatic long-bone disease between January 1999 and November 2020 to identify the impact of various treatment methods on postoperative survival. Researchers considered overall survival as the primary outcome and reviewed 90-day and 1-year survival with the Skeletal Oncology Research Group machine learning algorithm test.
“For statistical analysis, the Cox proportional hazards regression model was used to determine the effect of treatment modalities on survival,” Shimizu said in her presentation. “As for the model performance, we assessed that by creating a logistic regression model validating our temporal validation cohort.”
Shimizu said checkpoint inhibitors for targeted therapy had an association with increased survival, while chemotherapy was associated with worse overall survival. An analysis of patients who underwent treatment between 2016 and 2020 showed an association between a longer time on checkpoint inhibitors and improved survival. However, an increase in attempted therapies was associated with worse survival, according to Shimizu.
“Splitting the variables of systemic treatment to targeted [therapy] and chemotherapy resulted in a 0.02 increase in both 90-day and 1-year survival,” Shimizu said.
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Shimizu MR, et al. Paper 43. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting; Feb. 12-16, 2024; San Francisco.
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