VIDEO: Intra-articular antibiotic concentrations fall rapidly 24 hours following TKA
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Key takeaways:
- Intra-articular antibiotic concentrations fall for most bacteria following total knee arthroplasty.
- Antibiotic concentrations fall below the minimum inhibitory concentration for pathogens that cause infection.
SAN FRANCISCO — Levels of intra-articular antibiotic concentrations fall dramatically for most bacteria at 24 hours following total knee arthroplasty, according to results presented here.
“At 24 hours, the antibiotic concentrations fall below the minimum inhibitory concentration for most of the common pathogens that cause periprosthetic joint infection,” Juan D. Lizcano, MD, research fellow at Rothman Orthopaedic Institute, told Healio about results presented at the American Academy of Orthopaedic Surgeons Annual Meeting. “This is important because it shows that utilizing antibiotics in your bone cement gives you a peak of intra-articular antibiotic concentrations, but it falls rapidly.”
He added, “It is also important to analyze this type of data because the use of antibiotics in bone cement could lead to increased antimicrobial resistance and also increase costs for the surgery.”
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Lizcano JD, et al. Paper 130. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting; Feb. 12-16, 2024; San Francisco.
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