High chondrocyte viability allografts may be viable option for defects in ankle joint
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Key takeaways:
- Results showed high chondrocyte viability allografts may be a viable treatment option for defects in the ankle joint.
- atient adherence may also be a factor in patient outcomes.
LOUISVILLE, Ky. — Data showed high chondrocyte viability allografts may be a viable treatment option for symptomatic bipolar osteochondral defects in the ankle joint.
“High chondrocyte viability grafts, when compared to historical control, show substantially higher success rates and similar reoperation rates overall and when you account for unplanned reoperations, they are significantly lower,” Kyle Schweser, MD, said in his presentation at the American Orthopaedic Foot & Ankle Society Annual Meeting. “And we found that nonadherence increases your risk for graft failure, as well as less improvement in patient-reported outcome scores.”
In a retrospective cohort study, Schweser and colleagues collected patient-reported outcomes, including American Academy of Orthopaedic Surgeons foot and ankle pain scores and Patient-Reported Outcome Measurement Information System (PROMIS) physical function and mobility scores, among 14 patients with large, full-thickness symptomatic lesions. Researchers utilized radiographs to assess graft integration and joint space maintenance.
“We also wanted to see if protocol adherence was important for outcomes, and then we looked at reoperations,” Schweser said.
According to Schweser, 12 of 14 patients integrated the graft and maintained joint space. In addition, Schweser said AAOS foot and ankle pain scores and VAS pain scores improved significantly at each time point and reached clinically meaningful improvement.
“PROMIS physical function and mobility, while they did improve, they did not reach significance,” he said.
Schweser also noted patients who did not adhere to postoperative protocols had lower patient-reported outcomes at 1 year compared with those who did adhere to the protocols.
“In conclusion, we think advances in osteochondral allograft preservation and postoperative management have resulted in successful short-term outcomes for patients with this difficult problem,” Schweser said.
Schweser also noted patients adhere had patient-reported outcomes compared with those who did adhere.
“In conclusion, we think advances in osteochondral allograft preservation and postoperative management have resulted in successful short-term outcomes for patients with this difficult problem,” Schweser said.
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Schweser K, et al. Outcomes after bipolar osteochondral allograft transplantation in the ankle. Presented at: American Orthopaedic Foot & Ankle Society Annual Meeting; Sept. 20-23, 2023; Louisville, Kentucky.
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