Compared with several operative interventions, nonoperative treatment with functional bracing yielded the highest rates of nonunion and reoperation for patients with humeral shaft fractures.
Athan G. Zavras, MD, and colleagues performed a meta-analysis of 21 randomized controlled trials which analyzed 1,203 patients who were treated for humeral shaft fractures.
According to the study, 190 patients were treated nonoperatively with functional bracing; 479 patients were treated with open reduction and internal fixation (ORIF), 177 patients were treated with minimally invasive plate osteosynthesis, 312 patients were treated with antegrade intramedullary nailing and 45 patients were treated with retrograde intramedullary nailing. Outcome measures included time to union, nonunion, malunion, delayed union, reoperation, iatrogenic radial nerve palsy and infection.
Overall, researchers found patients in the functional bracing cohort had the highest nonunion rates at 17.4% compared with 5.2% in the ORIF cohort, 0.6% in the plate osteosynthesis cohort, 6.1% in the antegrade intramedullary nailing cohort and 6.7% in the retrograde intramedullary nailing cohort.. Results showed patients in the functional bracing cohort also had the longest mean time to union, as confirmed on radiograph. The functional bracing cohort had a reoperation rate of 20.5% vs. 5.2% in the ORIF cohort, 1.4% in the plate osteosynthesis cohort, 8% in the antegrade intramedullary nailing cohort and 6.7% in the retrograde intramedullary cohort, according to results.
Researchers noted minimally invasive plate osteosynthesis may be an “attractive option” that demonstrated successful results with the shortest mean time to union compared with other interventions.
“Regarding osseous union, operative techniques demonstrated better outcomes than nonoperative management with functional bracing, with the latter demonstrating significantly higher odds of nonunion and longer time to union,” Zavras and colleagues wrote in the study.