Higher rate of hip fractures found for patients with schizophrenia
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Key takeaways:
- Patients with schizophrenia had earlier onset and higher rates of hip fractures.
- Among patients with schizophrenia, there were sex-specific disparities in age of onset and rate of hip fractures.
Patients with schizophrenia experienced earlier onset and higher rates of hip fractures compared with the general population, according to study results published in JAMA Network Open.
In addition, researchers found sex-specific differences in the age of onset and prevalence of hip fractures among patients with schizophrenia.
“Our findings have important implications for evaluating osteoporosis management and post-hip fracture outcomes for a disadvantaged subpopulation,” Hina Ansari, MSc, of the Institute of Health Policy at the University of Toronto, and colleagues wrote.
In a population-based, cross-sectional study using data from health administrative databases in Ontario, Canada, Ansari and colleagues analyzed information for 109,908 patients aged 40 to 105 years with hip fracture-related hospitalizations between April 2009 and March 2019 to describe characteristics of patients with hip fracture and compare sex-specific annual hip fracture rates between patients with (n=105,657) and those without (n=4,251) schizophrenia.
According to the study, patients with schizophrenia and hip fracture had an earlier index event compared with patients without schizophrenia.
Men with schizophrenia had an average hip fracture onset age of 73 years vs. 81 years in patients without schizophrenia, whereas women with schizophrenia had an average onset age of 80 years vs. 84 years in patients without schizophrenia.
Patients with schizophrenia also had a higher rate of frailty and previous fragility fractures compared with patients without schizophrenia, according to researchers.
Moreover, patients with schizophrenia had a higher overall age-standardized rate per 10,000 individuals compared with patients without schizophrenia (37.5 vs. 16).
“These findings have important implications for targeted fracture prevention and optimizing clinical management of bone health in a vulnerable population,” the researchers wrote in the study.
“Further research is needed to elucidate sex-specific causal mechanisms underlying the increased burden and to evaluate outcomes and care for patients with schizophrenia who sustain a hip fracture,” they added.
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Ansari H, et al. JAMA Netw Open. 2023;doi:10.1001/jamanetworkopen.2023.10550.
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