VIDEO: Antibiotic-loaded calcium sulfate beads may be safe in high-risk patients
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Key takeaways:
- Serum creatinine was significantly higher postoperatively vs. the pre-surgical peak.
- Overall, 14% of patients required reoperation.
LAS VEGAS — Results showed use of antibiotic-loaded synthetic calcium sulfate beads may be safe and effective in patients at high risk for infection who are undergoing orthopedic procedures.
“Now, given the antibiotic protocol for calcium sulfate-based bone grafts, an increase in serum creatinine could be expected and should, therefore, be monitored given the renal toxicity of some of the antibiotics used, including vancomycin and tobramycin,” Nishant Suneja, MD, of Brigham and Women’s Hospital, told Healio about results presented at the American Academy of Orthopaedic Surgeons Annual Meeting. “Despite not being statistically significant from its preoperative peak, the observed post-surgical decrease in serum calcium may be suggestive of osteogenesis and fracture healing.”
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Zhou JJ, et al. Poster 252. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting. March 7-11, 2023; Las Vegas.
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