Kyphoplasty for vertebral compression fractures yielded higher mortality rate
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CHICAGO — Patients with vertebral compression fractures who underwent kyphoplasty experienced higher rates of mortality compared with patients who did not undergo kyphoplasty, according to results presented here.
“For further research when we have more numbers of patients who received kyphoplasty, we hope to collect and analyze this data again while also performing a patient match to better match the clinical characteristics between the kyphoplasty vs. non-kyphoplasty cohorts,” Vemmy Metsutnan, a third-year medical student from Virginia Tech Carilion School of Medicine, said in her presentation at the North American Spine Society Annual Meeting.
Among 2,829 patients who sustained vertebral compression fractures between 2015 and 2019, Metsutnan and colleagues categorized patients based on whether they underwent kyphoplasty (n=110).
“The primary outcome of mortality was investigated between the two cohorts by a Chi-square test or Fischer’s exact test,” Metsutnan said. “A survival analysis was also performed to analyze significant differences between the cohorts. Variables collected were also analyzed by time, and measures of associations were analyzed by variable pairings.”
Metsutnan noted a statistically significant association between mortality rate and kyphoplasty, with 21.82% of patients who received kyphoplasty reported as deceased vs. 13.68% of patients who did not receive kyphoplasty. A log-rank test of equality demonstrated no significant differences between the strata of survival between the two groups.
“Fracture type and mortalities associated with comorbidity were also examined and significant associations were found between mortality and diabetes, as well as renal disease,” Metsutnan said.
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Metsutnan V, et al. Paper 195. Presented at: North American Spine Society Annual Meeting; Oct. 12-15, 2022; Chicago.
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