Study: Orthobiologics are safe, effective for patients undergoing high tibial osteotomy
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According to published results, intra-articular orthobiologics injections are a safe and effective treatment with positive outcomes in patients undergoing high tibial osteotomy for knee osteoarthritis.
In July 2021, researchers performed a systematic review of literature from the PUBMED, EMBASE and CINAHL databases, which yielded eight studies and 585 patients who received intra-articular orthobiologics injections during high tibial osteotomy (HTO) for knee osteoarthritis (OA). Among the eight studies, two used platelet-rich plasma, four used bone marrow aspirate concentrate and four used mesenchymal stem cells. Two studies used dual orthobiologic agents.
Overall, no complications including deep infection or failure of prosthesis implants were reported, and the researchers noted “significant improvement” in cartilage repair and regeneration following HTO in multiple studies. They concluded intra-articular orthobiologics injections are safe and effective for patients with knee OA who undergo HTO.
“We hope that this systematic review will help lead the discussion and encourage researchers to conduct more robust Level I and II clinical and translational studies,” the researchers wrote in the study. “These would address factors and outcomes not discussed in this review such as, but not limited to, postoperative bleeding, cost-benefit analyses of treatment modalities and other orthobiologic agents.”
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