IV antibiotics led to adverse effects after revision shoulder arthroplasty
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Modification from oral to IV antibiotic administration led to increased complications and adverse effects after revision shoulder arthroplasty, according to published results.
Researchers analyzed 175 patients who underwent revision shoulder arthroplasty. Patients were treated with either IV antibiotics with a high index of suspicion for infection or oral antibiotics with a low index of suspicion for infection, according to the study abstract.
After multivariate analysis, researchers found male sex, history of infection and membrane formation as independent predictors for initiation of IV antibiotics.
“The modification from oral to IV antibiotics due to positive culture results was made significantly more often in male patients,” the researchers wrote. “Adverse effects of antibiotic administration occurred in 19% of patients. The rates of complications were significantly lower in the patients treated with oral antibiotics and a shorter course of antibiotics,” they added.
“Complications associated with antibiotic administration after revision shoulder arthroplasty are not infrequent and are more common in patients whose initial protocol is IV antibiotics,” the researchers concluded.
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