Choriocapillaris flow deficits appear lower in individuals with prediabetes
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Key takeaways:
- Mean flow deficit percentage was lower in the prediabetes group than the control group.
- Findings suggest a potential protective mechanism in response to early prediabetic changes.
INDIANAPOLIS — While it is known that choriocapillaris flow deficits can be a biomarker for diabetes, recent data presented at Academy 2024 indicated that prediabetic patients have lower flow deficit.
“Extensive research has already shown that an increase in choriocapillaris flow deficits occurs in patients with diabetes,” Brant Hoggatt, BS, a student at Illinois College of Optometry, said. “However, little attention has been given to prediabetic subjects in this regard, so our study aims to bridge that gap.”
Hoggatt and colleagues recruited 46 individuals — 16 controls (mean age, 35.2 years) and 26 with prediabetes (mean age, 43.7 years) — and obtained 3x3 mm fovea-centered images of the retinal and choroidal vasculature via the Zeiss Cirrus 5000 OCT with AngioPlex.
Using a flow deficit algorithm, the researchers found that the mean flow deficit percentage of control participants was 22.07% compared with 18.25% in prediabetic participants.
“Our findings in the prediabetic group compared to the control group suggest a potential protective mechanism, which could be analogous to the known thickening of the choriocapillaris in response to early prediabetic changes,” Hoggatt said.
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Hoggatt B, et al. Evaluating choriocapillaris flow deficits as a marker for prediabetes. Presented at: Academy 2024; Nov. 6-9, 2024; Indianapolis.
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