Study evaluates progression, risk factors for conversion from narrow angle to PACG
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The risk for progression from anatomical narrow angle to primary angle closure glaucoma is low and mainly occurs within 6 months of ANA diagnosis, according to a poster presented at Real World Ophthalmology.
In a study, Kristy Yoo and co-authors analyzed data provided by the Optum Clinformatics Data Mart health care claims database to identify patients diagnosed with anatomical narrow angle (ANA) between 2007 and 2019, assess the rates of diagnostic conversion to primary angle closure glaucoma (PACG) and evaluate the potential risk factors associated with conversion.
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A total of 3,985 cases of ANA were identified, of which 459 (11.52%) progressed to PACG within the study period; 211 (49.97%) progressed within the first 6 months of ANA diagnosis, and the yearly rate of progression was subsequently stable at 3.54%. Age older than 70 years, history of early laser peripheral iridotomy (LPI) and IOP-lowering medications were associated with a higher risk for progression, whereas cataract surgery was shown to lower the risk.
“ANA should be monitored more closely during the first 6-month time frame, especially among older patients receiving LPI or IOP-lowering drops,” the authors wrote. “Earlier cataract surgery should be strongly considered in ANA patients given its strong protective effect against PACG.”
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Yoo K, et al. Six-year rates and risk factors of progression from anatomical narrow angle to primary angle closure glaucoma in the United States. Presented at: Real World Ophthalmology; Nov. 5, 2022 (virtual meeting).
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