Short-term PFO endotamponade effective in some vitreoretinal surgery cases
NEW YORK — In certain cases, short-term tamponade with perfluoro-n-octane provides good anatomical and functional outcomes, according to a poster presented at the American Society of Retina Specialists annual meeting.
In a study, Katarzyna Chwiejczak, MD, FEBO, and co-authors retrospectively analyzed a series of 42 eyes of 42 patients who underwent vitrectomy with short-term perfluoro-n-octane (PFO) endotamponade at the Sydney and Sydney Eye Hospital between September 2019 and June 2021.
The participants presented with a variety of conditions, including giant retinal tears, retinal breaks, recurrent or complicated retinal detachment, and ocular trauma. All patients underwent vitrectomy and additional surgical maneuvers when needed, followed by injection of PFO. After 3 to 21 days, PFO was removed and replaced with a gas (SF6 or C3F8) or silicone oil tamponade. The mean follow-up time was 177.3 days.
Best corrected visual acuity improved in 70% of eyes, was stable in 11% of eyes and deteriorated in 19% of eyes. Final BCVA was positively correlated with initial BCVA, while no significant correlation was found with the duration of tamponade.
Complications included three cases of recurrent retinal detachment, seven cases of cataract, eight epiretinal membranes mainly in recurrent retinal detachment or post-traumatic cases, macular edema in seven eyes and intraocular inflammation in two eyes. Retained intracameral PFO occurred in five cases, and retained subretinal perfluorocarbon liquid occurred in one case. No toxicity was observed.
Short-term endotamponade with PFO can be an effective treatment option in vitreoretinal surgery, according to the authors.
“The final result depends on the complexity of the underlying pathology and initial BCVA, not length of the tamponade,” they wrote.
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Chwiejczak K, et al. Short-term endotamponade with perfluoro-N-octane as a safe and effective treatment option in vitreoretinal surgery. Presented at: American Society of Retina Specialists annual meeting; July 13-16, 2022; New York.
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